IgG Protease Program

A selective IgG protease designed to degrade pathogenic IgG while preserving broader immune function.

Key attributes:

• Subclass selectivity
• Reduced immunogenicity
• Redosable potential
• Broad applicability across IgG-mediated disorders

Engineered Cytokine Programs

Cytokines designed to separate anti-inflammatory signaling from unwanted pro-inflammatory effects.

Potential applications include:

• Inflammatory bowel disease
• Conditions marked by dysregulated cytokine networks
• Novel combinatorial cytokines

Ongoing Expansion

Our approach designs entire protein families, not isolated molecules. This creates a broad frontier in:

• IgA-mediated kidney disease
• Dermatologic autoimmune disorders
• Multimodal protease–cytokine strategies
• IgE mediated diseases