IgG Protease

Vision
To more safely and effectively treat diseases mediated by IgG antibodies.

Context
IgG antibodies are part of the body’s natural defense system but can lead to chronic autoimmune diseases in certain circumstances.

Problem
IgG proteases are bacterial enzymes that have been shown to cleave IgG. However, these proteases are non-specific and can trigger an immune response that affects their efficacy, stability, and redosability.

Evozyne Solution
Design novel IgG proteases that have several points of differentiation: higher activity and stability to minimize dosage, reduced immunogenicity to enable redosability, and increased specificity to disease-causing subtypes of IgG to increase safety.